Royal Institute of Technology Stockholm
The Royal Institute of Technology is the largest technical university in Scandinavia. A total of 210 researchers work in genomics, proteomics, bioautomation, biochemistry, structural biology and bioinformatics within the School of Biotechnology.
The Department of Proteomics, headed by Professor Mathias Uhlén, comprises seven research groups. In particular relevance to AFFINOMICS, it hosts the Human Proteome Resource (HPR) Centre having a facility for systematic high-throughput generation of validated affinity reagents, for which it has an international reputation. The resource provides tools for functional annotation of proteins using tissue profiling based on tissue microarrays and fluorescent-based analysis. It is also responsible for the public Human Protein Atlas portal. The present version of the database includes more than 3 million high-resolution images showing the spatial distribution of proteins in 48 normal tissues, 20 cancer types and 48 human cell lines (www.proteinatlas.org).
Role in AFFINOMICS: As a major infrastructure and provider in the area of affinity binders, KTH iw involved in several WPs. In WP1 they provide PrEST antigens for immunisation and selections, producing monospecific antibodies in WP2, and in WP3 they are a centre for access to QC assays using Western blot, immunohistochemistry, immunofluorescence and target arrays. In WP7 they have responsibility for the database of binders.