Paratopes Ltd (www.paratopes.com) was established in 2008 and is an official spin-out company of the European Molecular Biology Laboratory (EMBL). Paratopes is directed by the former head of the EMBL Monoclonal Antibodies Core Facility, Alan Sawyer, and makes classical hybridoma derived monoclonal antibodies at its custom-built research premises near Heathrow Airport in London, UK.
The laboratory is equipped with a high speed, high-throughput non-contact arrayer (Arrayjet) and a suite of sophisticated tissue culture robotics (Tecan) as well as a confocal 4-laser microarray scanner.
Paratopes uses proprietary screening technologies licensed from EMBL and advanced robotics platforms to increase throughput over conventional hybridoma platforms by up to 2000%
Alan Sawyer has been making monoclonal antibodies since 1988 and in addition to his role as head of the monoclonal core facility at EMBL was also the founding director of the Monash Antibody Technologies Facility in Melbourne, Australia.
Role in Affinomics: Paratopes generates hybridoma derived monoclonal antibodies (WP2) from WP1 supplied proteins and partially characterises the antibodies by microarray, western blot and ELISA before releasing them for downstream work packages.