Structural Genomics Consortium

The Structural Genomics Consortium is a public-private partnership established to facilitate drug discovery and further understanding of 3D structures of human proteins and proteins from pathological parasites. All generated data and reagents are made available to the public domain, without restriction on use. The SGC currently operates on two sites with laboratories at the Universities of Oxford and Toronto. A third lab at the Karolinska Institute in Stockholm was part of the SGC between 2005 and 2011.

Over the past 3 years, SGC scientists have been responsible for >25% of all new human protein structures reported worldwide (750 novel protein structures deposited to date). As a result, it has produced >1,500 human proteins in purified form and in milligram quantities. The SGC has a long history coordinating large scale projects with collaborators in industry and academia. It has coordinated a pilot study on protein binders, in which other partners of the current project have been involved: Dr Gräslund headed the project at the SGC and produced milligram amounts of 20 SH2 domains which were distributed to contributing laboratories. This effort has resulted in successful production of specific binders against most selected targets.