The University of Oxford
The University of Oxford is one of the largest Universities in the UK with 20,330 registered students in 2010. The University has been ranked at number 6 worldwide and is one of Europe's most innovative and entrepreneurial universities: income from external research contracts exceeds £340m p.a., and more than 60 spin-off companies have been created. For more information please visit www.ox.ac.uk.
The Nuffield Department of Clinical Medicine (NDM) is one of the largest departments of the University of Oxford and is part of the Medical Sciences Division, with a substantial research programme which requires high quality administrative management. For this purpose, the Department is split into six groupings, with the Old Road Campus Research Building unit forming one of these groups. The Oxford based part of the Structural Genomics Consortium is part of this unit.
Previous relevant experience: Scientists at the SGC Oxford have deposited more than 450 human protein structures. As a result, they have the ability to produce close to 1,000 human proteins in milligram quantities.
Role in Affinomics: The SGC Oxford will provide soluble proteins in milligram amounts for phosphatases (38) and other cancer related proteins (WP1). Initially, work will be focused on the catalytic domain of the phosphatases but generation of full-length protein and/or multidomain construct expression will be attempted wherever appropriate. In addition, SGC will use recombinant antibody fragments in co-crystallisation studies (WP6) in order to produce crystal structures of different proteins.